5-AMINOLEVULINIC ACID HYDROCHLORIDE

PRODUCT IDENTIFICATION
CAS NO. 106-60-5 (Base), 5451-09-2 (Hydrochloride)

5-AMINOLEVULINIC ACID HCl

EINECS NO. 226-679-5
FORMULA NH2CH2COCH2CH2COOH·HCl
MOL WT. 167.59
H.S. CODE

2922.50.5000

TOXICITY
SYNONYMS 5-Amino-4-oxopentanoic acid hydrochloride;
5-Amino-3-oxopentansaeure (German); ácido 5-amino-3-oxopentanoico (Spanish); Acide 5-amino-3-oxopentanoïque (French); gamma-Aminolevulinic acid hydrochloride; delta-Aminolevulinic acid hydrochloride; Aminolevulinic acid hydrochloride; 5-Aminolevulinate hydrochloride; Levulan; Levulan Kerastick;

SMILES

NCC(CCC(O)=O)=O.Cl

CLASSIFICATION

Aminolevulinate, Keto Acids, Dermatologic Agent, Hypoglycemic Agent, Photosensitizing Agent, Radiation Sensitizing Agent, Phototherapy.

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE

White crystalline powder

MELTING POINT 156 - 158 C (Decomposes)
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble
AUTOIGNITION  
pH  
VAPOR DENSITY 5.78
NFPA RATINGS Health: 1; Flammability: 1; Reactivity: 0

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY Stable under ordinary conditions. Hygroscopic.

GENERAL DESCRIPTION & APPLICATIONS
5-Aminolevulinic acid is an intermediate in heme biosynthesis in the body. Two molecules of ALA are condensed to form porphobilinogen. It is the first step compound in the porphyrin synthesis. Porphyrin is a class of cyclic tetrapyrrolic ring structure compounds joined by four methene bridges (=C-) through alpha-carbon atoms of four pyrroles. Porphyrins are water-soluble biological pigments occuring widely in animal and plant tissues to take part in important biological functions such as metal-binding cofactors in hemoglobins in the blood of animals, chlorophyll in plants for photosynthesis, and certain enzymes for cell respiration. Numerous types of porphyrins can be obtained through the modification of a natural porphyrins and total synthesis. Not only their chemical transformations through nucleophilic and electrophilic substitution, substituent modification, reduction, oxidation but also thier metalation and demetalation properties with iron, zinc, copper, nickel, and cobalt give valuable biological applications in molecular biology, fluoroimmunoassay, catalysts and new pharmaceutical developments.  

Wikipedia Linking: http://en.wikipedia.org/wiki/5-Aminolevulinic_acid
SALES SPECIFICATION

APPEARANCE

White crystalline powder

PURITY

98.0% min

WATER

0.5% max

ASH

0.5% max

HEAVY METAL

20ppm max

TRANSPORTATION
PACKING

 

HAZARD CLASS  
UN NO.

 

OTHER INFORMATION
FEMA Number: 2627
European Hazard Symbols: , Risk Phrases: 36/36/38-66, Safety Phrases: 26-36/37

GENERAL DESCRIPTION OF PHOTOSENSITIZING AGENTS
Photosensitizing agents such as Hematoporphyrin D are pharmacologically inactive but when excited by visible light or a specific wavelength concentrate selectively in metabolically active diseased tissue and are converted to active metabolite to produce a beneficial reaction affecting the tissue by the production of cytotoxic free radicals. Photosensitizers are used in the photodynamic therapy. Photosensitizers are administered topically or systemically and have been used therapeutically to treat psoriasis, acne and various types of neoplasms. Photosensitizing agents include:
Photosensitizing Agent

CAS RN
Acetophenone 98-86-2
Afloqualone 56287-74-2
alpha-Terthienyl 1081-34-1
Aluminum phthalocyanine disulfonate 68637-19-4
Aminomethyltrioxsalen 64358-50-5
Bacteriochlorin A 103428-20-2
Benzophenone 119-61-9
Benzoporphyrin D 113719-89-4
Bergamot oil 8007-75-8
Bergaptol 486-60-2
Bis(dimethylthexylsiloxy)silicon 2,3-naphthalocyanine 153454-02-5
Bis(tri-n-hexylsiloxy)(2,3-naphthalocyaninato)silicon 92396-88-8
Cadmium texaphyrin 115677-78-6
Carprofen 52263-47-5
Chlorin P6 22006-68-4
Chloroaluminum tetrasulfophthalocyanine 104469-80-9
Chloroaluminum-1,11,15,25-tetramethyl-tetrapyrido-porphyrazine 150437-07-3
Chloroaluminum-1,8,15,22-tetramethyl-tetrapyrido-porphyrazine 150437-06-2
Copper benzochlorin 145582-83-8
Ficusin 66-97-7
Fullerene C60 99685-96-8
Gilvocarcin V 77879-90-4
Hematoporphyrin dicyclohexanyl ether 119052-80-1
Hematoporphyrin D 68335-15-9
Hematoporphyrin dihexyl ether 111922-13-5
Hematoporphyrin diphenyl ether 119052-81-2
Hypocrellin A 77029-83-5
Hypocrellin B 123940-54-5
Lomefloxacin 98079-51-7
Lumin 80893-93-2
Lysyl chlorin P6 140395-23-9
Merocyanine 540 58823-12-4
meso-Chlorin e6 monoethylene diamine 147740-90-7
Methoxsalen 298-81-7
Monoaspartyl chlorin E6 110230-98-3
Nitrogen dioxide 10102-44-0
Ozone 10028-15-6
Polymyxin B nonapeptide 86408-36-8
Protoporphyrin IX 553-12-8
Pyrido(3,4-c)-7-methylpsoralen 85878-63-3
Riboflavin 83-88-5
Silicon phthalocyanine 135719-28-7
Talaporfin sodium 220201-34-3
Tetra(4-N-methylpyridyl)porphine 38673-65-3
Tiaprofenic acid 33005-95-7
Tin etiopurpurin 113471-15-1
Tin(IV) chlorin E6 128835-29-0
Trioxsalen 3902-71-4
Verdin 12713-07-4
Verteporfin 129497-78-5
Victoria blue BO 2390-60-5
Zinc tetrabenzylpyridoporphyrin 146190-75-2
Zn(II)-Phthalocyanine 14320-04-8
1,6-Diphenyl-3-hexene-1,5-diyne 27370-85-0
1,9-Dimethylmethylene blue 23481-50-7
1-Pyrenemethyl-23,24-bisnor-5-cholen-22-oate-3beta-yl oleate 72535-39-8
2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a 149402-51-7
2,3-Naphthalocyanine 23627-89-6
2,4-Bis(1-decyloxyethyl)-Ga(III)-1,3,5,8-tetramethylporphyrin-6, 7-dipropionyl diaspartic acid 135099-39-7
2,6-Dimethyl-9-methoxy-4H-pyrrolo(3,2,1-ij)quinolin-4-one 131195-83-0
3,7,12,17-Tetramethyl-21H,23H-porphine-2,18-dipropanoic acid 448-65-7
4-Methoxycinnamate methyl ester 832-01-9
5-(N-Hexadecanoyl)aminoeosin 114586-25-3
5,10,15,20-Tetra(4-hydroxyphenyl)porphyrin 51094-17-8
5-Aminolevulinic acid 106-60-5
6-Methylthionecoumarin 60257-28-5
8-Methoxythionepsoralen 72142-97-3